From the information society humans enter, the development of communication technology has making miraculous progress. As the popularization of communication, a variety of Interference in transport channel increases dramatically. That how to transport information efficiently and correctly under the adverse circumstances has become a rough problem the researcher of communication has to face with Spread spectrum communication is a kind of communication patterns in which the band bandwidth used to transport information is far larger than the original signal. Compared with the traditional wireless communication, it has many unparalleled advantages on the performance of anti-noise, anti-jamming, fighting against multi-path fading, code division multiple access and the elusive and confidentiality of the signal. It has become the three major communication patterns with the fiber communication and satellite communications. This text mainly expound that how to simulate the DS-CDMA system use the SIMNLINK software and study it’s superior capacity of anti-noise, anti-jamming, fighting against multi-path fading and code division multiple access. The main body of this article as follows: 1. Studying the main technology theoretically in Spread spectrum communication; 2. Depicting some current mode, including digital matched filter for capture, L L-DPLL for coder tacking and so on; 3. Illuminating how to use the SIMULINK software to simulate the DS-CDMA system; 4. Analyzing the performance of the DS-CDMA system combined with the consequence of simulation. Keyword: spread spectrum communication; simulink; DS-CDMA