Goal: The discussion lower limb vein thrombus (deep venous thrombosis, DVT) forms is one of old age coxa bone fracture most common complications, Qi Bao celebrates and so on to report, if does not carry on the intervention, adopts the conservative treatment the old age coxa bone fracture patient, the DVT formation rate is 56.67%.The 19th century intermediate stages, French Virchow most early proposes the phlebothrombosis three big factors: The vein blood stream is slow; Vein wall damage; The blood congealed condition still to recognize until now high as the various countries' scholar.DVT good sends the spot is a lower limb, after orthopedics major surgery, DVT may create the body disability common, even continues sends the lethality pulmonary embolism (pulmonaryembolism, PE), thus it can be seen DVT prevention important .The advanced age, the hip department wound and the surgery are DVT high-risk factor . Method: Coxa bone fracture patient's most is the senior citizen, often merges the multi-systems, the multi-organ physiology draws back changes with (or) the organic pathological change, the blood is at congeals high the condition; In front of because these patient technique many moves reduces obviously, after the technique the margin ache, the anaesthesia response and so on cause the activity to receive obviously limit, cause the lower limb blood stream to be at the slow condition.Simultaneously the blood return to original state viscosity and the fibrinogen advance also are form DVT the factor.Because it is neglected extremely easily, the most patients have not been able to obtain the prompt diagnosis, not only the influence the primary affection treatment, also extremely easy to evolve the thrombus to form the sequela. The lower limb deep phlebothrombosis are most main and the common sequela, is the lower limb deep phlebothrombosis synthesis drafts.Affects the patient to live for a long time, the minority patient may have the pulmonary embolism, threatens the safety seriously.
At present in the world generally uses the low molecular heparin prevention to treat DVT the occurrence: Finally: During the low molecular heparin is produces the heparin after chemistry or the enzyme depolymerization the mean molecular weight in 4000~6500 heparin fragments.Because the molecular weight is small, is formed in the thrombus the blood platelet to release not easily the blood the blood plateletⅣFactor neutral, the antifreeze effect and the filament dissolve the function to be able to strengthen, but the anti-blood platelet, the suggestion hemorrhage function for is weaken greatly, is minimum to the lipin metabolism influence, adds the biological exploitability to reach as high as 98%, measures the effect relations is clear about, when the fixed dosage prevents clotting the effect easy to forecast, blood plasma half-life ordinary heparin long 2~3 times, do not penetrate the placenta barrier, for example, the release organizes the factor way inhibitor (tissuef actorp athwayi nhibitor, TFPI) and theorganization plasmin original activation element, the adjustment cell adhesion member, presses the filament from the blood vessel wall release to fuse theanti-thrombus medium, causes in the blood circulation von the Willebrand factor and sends the phlogocyte factor to reduce, but also has to the blood rheology influenceAs well as affects TFPI with the blood platelet and the white blood cell is mutually the extraneous source hemoglutination way physiology inhibitor, Conclusion: Therefore carries on the positive effective antifreeze is treats the old age coxa bone fracture patient vein thrombus the important method, moreover we have already obtained the satisfying effect.
