Abstract:Neohexene is an important intermediate of fine chemical, is widely applied in the chemical synthesis of aromatics and agrochemicals. Two synthesis route were proposed based on literatures and comprehensive comparison. One is through two-step synthesis process: pinacolone is firstly reduced by sodium borohydride to 3,3-dimethylbutan-2-butanol, which then is dehydrated to give neohexene. The other involves three steps: first, pinacolone reacts with sodium borohydride to get 3,3-dimethylbutan-2-butanol, which is then converted to 2-chloro-3,3-dimethylbutane, and from which the hydrogen chloride is finally removed to obtain neohexene. The aim of this work is to investigate the process conditions for the two routes of neohexene synthesis. In the final analysis, the three-step method is determined as the propriate synthesis route for neohexene.
key word:Neohexene; 3,3-dimethyl-2-butanol; 2-chloro-3,3-dimethylbutane; Dehydration; Elimination