Abstract: Ethyl-trifluoroacetoacetate is used as important intermediate in the synthesis of pharmaceutical or plant protection industry. This paper describe a way of preparation of ethyl-trifluoroacetoacetate by following steps . In the first step, ethyl-trifluoroacetate condensed with ethyl acetate in the presence of alkaline catalyst. The follow steps are neutralization and acetylation, then optimize the reaction conditions of the preparation of ethyl-trifluoroacetoacetate. The study show that the optimal reaction conditions as following: cyclohexane as solvent, 1.2 equivalent of sodium for catalyst, reactant molar ratio is 1 : 1.5, condensation reaction for 4 hours, formic acid for neutralization and 1 equivalent of chloride for acetylation, the yield of ethyl-trifluoroacetoacetate is 78%.