TAED在醋酐中的溶解度和结晶介稳区的研究

制药工程论文编号:ZY109    论文字数:12643,页数:38

 Ⅱ
 目  录
中文摘要...........................................................I
英文摘要...........................................................II
目录...............................................................Ⅲ
1. 绪论............................................................1
 1.1  TAED产品简介...............................................1
  1.2  合成TAED的生产工艺.........................................1
 1.2.1  一步法合成TAED.........................................1
 1.2.2  两步法合成TAED.........................................2
 1.2.3  合成TAED的催化方法选择..................................3
 1.3  制备TAED的后续处理步骤......................................4
 1.4  结晶热力学基础..............................................4
 1.4.1  溶解度的概念............................................4
 1.4.2  溶解度的测定方法........................................5
    1.4.3  超溶解度的概念..........................................5
 1.4.4  超溶解度的测定方法......................................5
 1.4.5  介稳区的概念和介稳区宽度的计算方法......................6
 1.5  结晶动力学基础知识..........................................7
   1.5.1  成核....................................................7
   1.5.2  晶体生长................................................8
 1.6 本课题研究的意义.............................................9
2. 实验部分........................................................9
 2.1  实验原材料和仪器............................................9
    2.1.1  实验原材料..............................................9
    2.1.2  实验仪器................................................9
  2.2  实验操作过程................................................10
 2.2.1  饱和溶解度测定操作......................................10
 2.2.2  超溶解度的测定..........................................11
 III
 
3. 结果与讨论......................................................11
 3.1  TAED在醋酐中的饱和溶解度....................................11
  3.2  TAED在醋酐中的结晶介稳区宽度................................12
    3.2.1  降温速率对结晶介稳区宽度影响........................... 13
    3.2.2  搅拌速度对结晶介稳区宽度影响........................... 23
4. 总结展望........................................................31
致谢...............................................................32
参考文献...........................................................33

摘要：四乙酰乙二胺( TAED)是一种性能优良的过氧化物漂白活化剂，结晶是TAED生产过程中的重要步骤之一，对TAED生产工艺的收率和质量指标有重要影响。溶解度和介稳区宽度是结晶过程的基础研究内容之一。采用激光散射法测定了四乙酰乙二胺（TAED）在醋酐溶液中于不同降温速率，搅拌转速下的结晶介稳区宽度。并用最小二乘法对实验数据进行回归，得到不同的降温速率下介稳区宽度△Tmax与浓度的关系，不同搅拌速率下介稳区宽度△Tmax与浓度的关系。结果表明：随着降温速率的增大，介稳区明显变宽；随着搅拌速率的增大，介稳区明显变窄。
关键词：四乙酰乙二胺；醋酐；结晶介稳区；激光散射法

Abstract：Tetraacetyl ethylenediamine (TAED) is a kind of good peroxide bleaching activators. Crystallization is an important step in the process of production, which has important influence on yield and quality of TAED in production process. Solubility and the metastable zone width is the one of the basic researchments in crystallization process. Using laser scattering method for measurements of crystallization metastable zone width and solubility of the teraacetyl ethylenenediamine (TAED) in acetic anhydride solution at different cooling rate, stirring speed. Measuring the metastable zone width △Tmax interface with concentration at different cooling rate, measuring the metastable zone width △Tmax interface with concentration at different stirring speed stability, Using least-square method of experiment data regression. The results show that, the high cooling rate increase the metastable zone width △Tmax, high stirring speed decrease the metastable zone width △Tmax.

Keywords： Tetraacetyl ethylenediamine；Acetic anhydride; Crystallization metastable zone;  Laser scattering method