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Abstracts: Norfloxacin is a broad-spectrum antibiotic, and there are a good deal of methods for synthesizing it. However, forming boride is the most important method. And this paper       mainly analyses 4-dihydro-4-oxo-3-quino-carboxylic ethylic ester; 1-ethyl-7-chlo-6-fluoro- 1,4-dihydro-4-oxo-3-quino- carboxylic ethylic ester and boride which are the crucial intermediates for synthesizing Norfloxacin . Firstly to learn their physical-chemic characters, then to insure their analytical methods with  High Performance Liquid Chromatography and to select analytical conditions . 
 As a result, at normal atmospheric temperature on an ODS (150*6.0mm) column, at a flow-rate of 1ml/min, and monitored by ultraviolet detection, detected at 254nm, using methanol and 0.02mol/L lemon acid with the proportion of 80 and 20 as mobile phase, the 4-dihydro-4-oxo-3-quino-carboxylic ethylic ester can be separated with the resolution of 1.556; using acetonitrile and 0.005mol/L potassium dihydrogen phosphate with the proportion of 55 and 45 as mobile phase , the 1-ethyl-7-chlo-6-fluoro-1,4-dihydro-4-oxo-3-quino- carboxylic ethylic ester can be separated with the resolution of 1.523;  and using acetonitrile and 0.005mol/L potassium dihydrogen phosphate with the proportion of 60 and 40 as mobile phase, the boride can be separated with the resolution of 1.612.
 
Key words: Norfloxacin; Boride; High Performance Liquid Chromatography