年产1000吨对甲砜基甲苯的车间生产工艺设计

制药工程论文编号:ZY060    论文字数:13234,页数:36

 目录

中文摘要……………………………………………………………………………I
英文摘要……………………………………………………………………………II      
目录…………………………………………………………………………………III
绪论………………………………………………………………………………… 1
1．前言………………………………………………………………………………2
 1.1 对甲砜基甲苯的概述………………………………………………………2
 1.2 对甲砜基甲苯的合成方法比较…………………………………………  3
2．对甲砜基甲苯车间工艺的设计计算……………………………………………5
   2.1 设计内容……………………………………………………………………6
 2.2对甲砜甲苯的生产工艺流程图的确定…………………………………… 7
 2.3对甲砜基甲苯的生产周期的确定………………………………………… 7
 2.4 年产1000吨对甲砜基甲苯的物料衡算……………………………………8
 2.5 能量衡算……………………………………………………………………10
 2.6 设备选型………………………………………………………………… 18
3．车间布置的设计……………………………………………………………… 22
 3.1 设备布置原则………………………………………………………………22
 3.2设备布置设计的步骤……………………………………………………… 22
 3.3环境保护与安全措施……………………………………………………… 22
4. 三废处理情况……………………………………………………………………23
 4.1 安全卫生与劳动保护……………………………………………………… 23
 4.2车间安全措施要求………………………………………………………… 24
 4.3 卫生措施…………………………………………………………………… 24
5. 讨论与结果………………………………………………………………………29
 5.1 物料衡算结果……………………………………………………………… 29
 5.2 能量衡算结果……………………………………………………………… 29
 5.3 设备选型结果……………………………………………………………… 29
6.结论与展望……………………………………………………………………… 31
 致谢…………………………………………………………………………………21
 参考文献……………………………………………………………………………32

摘要：对甲砜基甲苯是一种重要的医药化工原料，其传统的制备工艺因“三废”排放较多而易造成环境污染，本设计是先用对甲苯磺酰氯为原料，先用碳酸氢钠和亚硫酸钠为还原，通过不同的甲基化试剂进行对比，最终用氯乙酸为甲基化试剂合成对甲砜基甲苯的制备方法；该设计合成工艺具有反应条件温和、操作安全、生产成本低、生产周期短、收率高、原料廉价易得、基本无“三废”排放等绿色化学特点，更适合工业化生产。编制一份年产1000吨对甲砜基甲苯生产车间的工艺设计说明书，对物料、热量、车间布置等进行研究。根据工艺特点通过物料衡算得到每一种所需原料的质量；通过热量衡算得到所需传递的热量；最后选出了甲基化反应釜、真空干燥器、离心过滤器及车间布置等方面的设计、环境保护和安全措施，最后给出了生产工艺的反应流程简图、车间布置图。
关键词：对甲砜基甲苯；对甲苯磺酰氯；物料衡算

 Abstract  Methyl sulfone toluene is an important chemical raw material medicine, the traditional preparation for the "three wastes" discharge more obviousness of environmental pollution, This design is the first use of tosyl chloride as raw material, first with sodium bicarbonate and sodium sulfite reduction,Methylation by different reagents were compared with chloroacetic acid as the final synthesis of a methylation reagent toluene sulfonyl Preparation;Its features is to tosyl chloride, anhydrous sodium sulfite, sodium bicarbonate, chloroacetic acid for the synthesis of raw materials; And on reaction conditions (including reagents, reaction time, reaction temperature, etc.) to improve and optimize. The new synthesis has mild reaction conditions, operational safety, low cost, short production cycle, high yield, raw materials cheaper, and basically no "three wastes" emissions such as green chemistry, it is more suitable for industrial production. The preparation of a 1000 tons of methyl sulfone toluene workshop process design specifications for materials, energy, kettle body, facility layout and other research. According to the technical characteristics of material balance obtained by each of the required quality of raw materials; through the heat balance to obtain the required heat transfer; Finally selected methylation reaction kettle, vacuum dryers, centrifugal filters and shop layout and other aspects of design, environmental protection and safety measures,given the reaction process simple production process maps, shop layout.
 
Key words  p-toluenesulfonic acid; p-toluene sulfonyl chloride; mass  balance;