Abstract Objective: To improve the drug effect of aspirin, reduce its side effect, we sucessfully synthesize chitosan-aspirin conjugate with lower side effect.In this paper chitosan-aspirin was synthesized via EDC and NHS in normal pressure and room temperature. The product was characterized by FT-IR、UV and DSC. The drug-loading rate of product reached upto30.93% measured by HPLC and the conversion rate of aspirin reached upto 21.70%. Then we pilot studied the hygroscopicity and pH stability of the conjugate. The research results showed the humidity of the conjugate obvious increased in more than 64.0 percent moisture; the conjugate relatively was stable between.pH6.0 ~ pH7.0.
Key Words:Chitosan;Aspirin ; Coupling inspect