Abstract: This thesis is to introduce the preparation of reversibly thermosensitive chitosan-glycerophosphate hydrogel, and the investigation of its’ temperature sensitive properties and drug release behaviors. Firstly, the deacetylation degree and the viscosity average molecular weight of chitosan were determined. And then chitosan and glycerophosphate were made into semi-interpenetrating network hydrogel through the physical blending method. The effects of different mass ratio of chitosan to glycerophosphate and different pH on gelation properties of this chitosan-glycerophosphate system were studied. This chitosan-glycerophosphate hydrogel was characterized by infrared absorption spectrometry, and the phase transition curve was obtained through transmittance measured by UV spectrophotometer. Glycerol phosphate(mass concentration 56%) and chitosan (mass concentration 2% ) in the volume ratio of 0.2, adjusting the solution pH to 6.9 to prepare thermosensitive hydrogel, curcumin as a model drug, the cumulative release rates of curcumin were measured in three PBS buffer under 37 ℃, 40 ℃. The experimental results show that chitosan-glycerophosphate hydrogel can fast gelled (<260S) when temperature above 37 ℃, and the cumulative release of curcumin hydrogel was significantly lower than that of curcumin solution. Therefore, this temperature sensitive hydrogel can be used as drug sustained release carrier.