Abstract: The molecular weight of Pyrithionc Zinc is 317.7, Appearance is a milky water spread、Gray solid. Having to kill a fungus role, With the treatment of fungal infection, Reported by z pt lotions is quite safe. For local can absorb some of the drug (0.05% - 0. 8 %), The rich keep the sulphur is the effect of zinc. With z p t, can keep fresh fruit, fruit, high quality and can anniversary provide.
This article mainly adopt HPLC of zpt content of the testing . This method is simple, fast, reliable and can be validated to improve the quality control of ZPT. The chromatographic separation was performed on a Diamonsil Cl8column(250 mm × 4.6 mm id, 5 μ m particle size). After several tests by changing the type of mobile phase, ratio and pH value, etc., a HPLC method using an elution with lAcetonitrile-Methano and 10mmol / L monopotassium phosphate and 0. 5mmol\l L EDTANa2 aqueous solution (pH=4.14, adjusted by phosphoric acid)( 50∶ 10∶40 ,V / V / V) at a flow-rate of 1.0 mL / min has been developed. At ultraviolet wavelength 230nm, the standard curve equation of zpt Y=9299.5X-18030, R2=0.9997, plus recovery of 101.90 percent , RSD to 0.96 %, precision of 0.13 % .
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Key words: high-performance liquid chromatography (HPLC); zinc pyrithione; Cu2+ complex of pyrithione baicalin; Detection