Abstract: Chiral amino alcohol has extensively applicates in the asymmetric synthesis and intermediate areas, and a lot of scientific research personnel have deep interests in it . In this paper, the inspection on the basis of the relevent information summarizes the asymmetric catalytic reduction of new progress.
In order to find high performance, based on more catalysis center ligand in asymmetric catalytic reduction of synergies, can achieve available chiral secondary alcoholshigher e.e. value. We were using the natural ephedrine (-), (1 R, 2S )-(-) and (1 S, 2R )-(+)- 2 - amino-1,2 - diphenyl ethanol as chiral sources with 1,3- benzyl bromide reaction by optimizing reaction conditions in ethanol solution, in the 60-75 ℃, KI as a catalyst, K2CO3 as a hydrogen absorption reagent first synthesized the catalysis center with the ligand: N-methyl-N-(1′S, 2′R)-(1′-methyl-phenyl-2′- hydroxy) ethyl -1′,3′ benzylamine; N-(1′R, 2′S)-(1′,2 ′diphenyl -2′- hydroxy) and N-(1′S, 2′R)-(1′,2 ′diphenyl -2 ′- hydroxy) ethyl–1′,3′ benzylamine, by silica gel column chromatography get the colorless crystal, yields are higher. Product by the IR、MS and 1HNMR,etc. confirmed.The other physical constants are good.