Abstract: Methyl-2,3-O-isopropylidene-β-D-ribofuranoside was prepared from D-ribose protected by 2,2-dimethoxypropane. Methyl-2,3-O-isopropylidene-5-o-trifluoromethanesulfonyl -β-D-ribofuranoside glucoside was synthesized from methyl-2,3-o-isopropylidene-β-D- ribofuranoside and TSCl. Then Methyl-2,3-o-isopropylidene-5-o-trifluoromethanesulfonyl-β- D-ribofuranoside glucoside was reduced by NaBH4 to get methyl -2,3-O- isopropylidene-5- deaeration - beta -D- ribofuranose glucoside. Through the optimization and improvement of original process , this reaction is simple, duplicates well, reaction time is short, preceeds smothly, and the product is easy to purify, has the wided application in the industry.