Studies on the Synthesis of (E)-N-Functionalized Acrloyl-2,5-pyrrol- idinedione
Abstract:(E)-N-functionalized acryloyl -2,5-pyrrol- idinedione (FAPDs) have physibiological and pharmacological activities and are the important intermediate for preparing medicines and pesticides, so there are practical and academic merits in synthesis of FAPDs. We prepared FAPDs by a novel method, using carboxylic acid chlorides, as an acylating agent, with succinimide or phthalimide in the presence of hydride sodium and then investigated the influence of different solvents on the key procedure-N-acylation reaction and found ionic liquids were the best solvents. Nine FAPDs including the alkyl and aryl substituted were prepared.