Abstract: This article reviewed the synthesis and the application of benzene boric acid's s, and introduced its trend of development. Then we conducted the research of the o-position substituting group of benzene boric acid's and improved its technics, studied and improved the relative substituent benzene boric acid’s preparation craft, thus has determined the respective optimized synthesis condition. The article used orthogonal design experiment analytic method to analysis various factors like reaction time, the reaction temperature and the reactant material quantity to compared with the relative substituent benzene boric acid production rate’s affections, it had determined that among the relative substituent benzene boric acid’s production rate affect factors, what affected biggest was the reaction temperature, other were in turn the reaction time and the reactant material quantity ratio, the determination optimization synthesis condition are: The pro-nucleophilic substitution temperature for - 20℃, reactant confrontation bromine relative substituent benzene and the trimethyl borate material's ratio of quantity was 1/1.5, the reaction time was 140 min, the overall yield reaches as high as 69.5%; In addition, the article had also analysis the goal produce with the mass spectrum and the highly effective liquid chromatography, finally indicated that the obtained product was consistent with the goal product structure..
…
Keywords：4-tert-Butylphenylboronic acid; Synthesis;Characterization
