Study on the New Synthetic Process of Croconic Acid
Abstract:The crocic acid is in the center a kind of important chemistry body, the use is very extensive.The crocic acid is used for living creature analysis realm, is the near red and outside fluorescence dyestuff that combines with the living creature member covalence at present.In addition the crocic acid dyestuff is a type of new near and red outside absorption dyestuff, in order to having, the good light heat stabilizes to go to give out light to go with fluorescence ability, as a result at optical record with saving the realm have latent of applied value.Studied a lately synthesizing of the crocic acid route, take tetrachlorobenzoquinone as raw material, Be turned by AN oxygen radicle, water solution, oxidize to take off Zui three step systems Gao Chun Du's crocic acid.The traditional method for making setting out with two Quans from B compares, the route's raw material easily get, the condition is moderate, always accepting a rate cans reach to 35%, is farer high than about 10% of traditional method.Respond to set out and synthesize Gao Chun Du's crocic acid from the tetrachlorobenzoquinone.((or4,5-dihydroxy-4-cyclopentene-1,2,3-trione)The whole reaction passes six researches of steps, and got the best condition of reaction, concretely as follows:
1)The methyl alcohol aqua used in the etramethoxy process have to in order to have no water methyl alcohol, the aqua cools off the temperature of empress 15 ℃ before the reflux responds, then the further reflux responds;
2)AN oxygen radicle benzene Mao water solution reaction process in, the hydrogen bromine is sour with acetic acid Mo Er compare for 1:be tetrahydroxy and 2 mols at 1:00|weigh to crystallize in the L hydrochloric acid aqua, the product accepts to lead superior turn;
3)The product accepts to lead while making to join the measuring of oil of vitriol as 0.4 mls in the process of crocic acid the most ideal.
After excellent craft condition for turning compare traditional route reaction the condition is moderate and accept to lead higher, developed a new path for a great deal of making and industrialization production of crocic acid.
Keywords:crocic acid;tetrachlorobenzoquinone; etramethoxy-1, 4-benzoquinone; tetrahydroxy-1, 4-benzoquinone;synthesis