Structural modification of Berberine Abstract In this paper, the purpose of the study is to find a simple, quick and efficient method of directly modified so that the appropriate place of drug molecules to introduce the appropriate group modified to improve drug efficacy.Today, cardiovascular disease has become one of the major diseases that threat to human health . Study found that berberine has a good cardiovascular pharmacological activity, the paper bases on the original pilot of berberine for the structural modification, ultimately determine the appropriate structure of the drug modified conditions. The main experiment is: (1) Berberine with sodium borohydride to restore the tetrahydrocannabinol original berberine；(2) the tetrahydrocannabinol original berberine with the corresponding reaction in the hydrocarbon halogen-tetrohydroberberine Quaternary ammonium compounds.
Key words：Berberine ； Tetrahydrocannabinol original berberine ； Chemical group structure modification；
