Abstract: Ethyl-trifluoroacetoacetate is used as an important intermediate in the synthesis of pharmaceutical or plant protection industry. Ethyl-trifluoroacetoacetate is prepared by Claisen condensation of Ethyl-trifluoroacetate and ethyl acetate. The catalyst of the reaction is sodium hydride, sodium or sodium ethoxide. By comparing of the effect of these catalysts to the yield, the result indicates that preparing by the following way, the yield can reach the maximum 75%: In the first step, Ethyl-trifluoroacetate is condensed with ethyl acetate in the presence of sodium ethoxide. In the second step, the condensation product is neutralized with a protonic acid, such as formic acid. In the third step, the neutralization slurry is acetylized with acetyl chloride. At last, the Ethyl-trifluoroacetoacetate obtained is separated by distillation. The most important factor of this process is the temperature of reaction. The results of the experiment show that the best temperature of reaction is between 65 to 70℃. Keywords: Ethyltrifluoroacetoacetate; Sodium ethoxide; Claisen condensation